アブストラクト
| Date | February 3, 2011 |
| Speaker | Prof. Tadashi Yamamoto, Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University |
| Title | Human Proteome Project and Kidney Disease Project |
| Abstract |
The Human Proteome Project (HPP) has been launched at the 9th Annual
HUPO World Congress in Sydney, Australia, on September 23, 2010 by Human
Proteome Organisation (HUPO). The success of the Human Genome Project
has provided a blueprint of genes encoding the totality of proteins (the
human proteome) in the human body, however, we still have limited
knowledge about a significant fraction of the approximately 20,300
gene-coding human proteins. Based on the UniProtKB/Swiss-Prot database
content, about 6000 (30%) of these genes currently lack any experimental
evidence at the protein level, and for many others, there is very little
information related to protein abundance, distribution, or subcellular
localization, interaction with other biomolecules, and function. HUPO
aimed to map all the proteins in human body with the information, which
are made feasible by recent substantial advances in three representative
proteomics methods specifically related to 1) quantitative mass
spectrometry (MS), 2) protein capture with antibodies, and 3) global
exchange of large primary datasets and databases.
In the seminar, the concepts of HPP and contribution of personal proteomic biology projects and national “Adopt a chromosome project” are introduced. Kidney and Urine Proteome Project was organized to aim to understand kidney diseases and to discover urine biomarkers by international collaboration. This project is preparing proteome databases of human kidney and urine, which will be presented in my talk. http://www.med.niigata-u.ac.jp/npa/en.html |