| Date |
Nov 11, 2013 |
| Speaker |
Prof. Hanah Margalit, The Hebrew University
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| Title |
The multifaceted impact of post-transcriptional regulation by non-coding RNAs
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| Abstract |
Until recently, our view of gene expression regulation was dominated by transcription factors and transcription regulation. This has dramatically changed with the discovery of a whole new world of non-coding RNAs (ncRNAs), regulating gene expression post-transcriptionally by binding to mRNA molecules, affecting their stability and/or translation. While regulation by ncRNAs was shown to be widespread in both pro- and eukaryotes, a full understanding of the principles and properties of this regulation, as well as its local and global effects in cellular regulatory networks, is still lacking. In my talk I will describe our studies of the dynamic properties of post-transcriptional regulation, its integration with transcription regulation to form complex regulatory circuits with designed functionality, and the effects of competition between ncRNAs. I will discuss a novel type of connectivity that we discovered in the post-transcriptional regulatory network and its far-reaching implications on perturbations effects.
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