ゲノム情報科学研究教育機構  アブストラクト
Date October 2, 2006
Speaker Prof. Mats Wahlgren, Department of Microbiology, Tumor-and Cellbiology (MTC), Karolinska Institutet, and the Swedish Institute for Infectious Disease Control, Stockholm, Sweden
Title Understanding Severe Malaria
Abstract   Two forms of abnormal adhesive capability, cytoadhesion to the vascular endothelium and rosetting - binding of normal erythrocytes around parasitised ones - are thought to be the principal factors behind the particular virulence of Plasmodium falciparum malaria by promoting the sequestration of erythrocytes in the microvasculature Adhesion to both red blood and endothelial cells has been associated with the development of knobs, i.e. electron-dense surface membrane protrusions, one of many major morphological, functional and antigenic changes of the red cell induced by the intraerythrocytic development of the P.falciparum parasite. After being transported from the internal parasite, adhesins involved in the binding to other cells are concentrated and subsequently exposed to the exterior of the erythrocyte membrane at the knobs. Two parasite derived groups of antigen have been suggested to hold roles as adhesins, PfEMP1 and the RIFINs. The role of each of these in the sequestration of infected erythrocytes and their roles in the pathogenicity mechanisms of the disease will be discussed.
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