| Date |
October 16, 2006 |
| Speaker |
Dr. Yoshinobu IGARASHI, Burnham Institute for Medical Research |
| Title |
CutDB - a proteolytic event database |
| Abstract |
Proteolytic events are involved in multiple aspects of regulation
in eukaryotic cells and play a major role in many diseases, including
viral infections. However, the information on proteolytic events is
dispersed in original papers, and as a result, is not amenable for
large-scale analysis. CutDB is one of the first systematic attempts
to collect such information and present it in an easy to access form.
CutDB offers not only easy-searchable interfaces to retrieve the data
including a clickable network diagram but also has a community
annotation option based on a Wikipedia approach. Users can modify the
content using designated structured fields with/without an input
assist system, as well as express their opinion and provide additional
information as free text. CutDB allows and welcome contribution by
users, and is currently expanding at a high pace aided by dozens of
volunteers. So far, we specifically focused on protelytic events
involving matrix metalloproteases. Our ultimate goal is to reconstruct
proteolytic pathways in a broad biological context. This effort will
allow us to improve understanding of the role of proteolysis in
various biological processes. CutDB is publicly available at http://cutdb.burnham.org.
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