ゲノム情報科学研究教育機構  アブストラクト
Date September 13, 2011
Speaker Prof. Huarong Zhou, Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for Pre-Diabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Title Type 2 diabetes, is it an intestinal disease?
Abstract Type 2 diabetes is one of the systemic complex robust diseases. Once one is diagnosed to be the diabetics, the diseases will robustly progress, against the current medicine or life style intervention. Surprisingly, a bariatric surgery on the intestine, which was first designed for severally obese patients, attains at about 83% diabetes remission rate, and indeed, its rate has remarkable impact on the diabetes study. Apart from the clinical remission, the underlying mechanism for breaking disease progression pattern and curing diabetes by intestine surgery is still unknown at the molecular levels. In this talk, we will introduce our preliminary investigations which suggest that the diabetes is in close relationship with the intestine at phenotype levels. Furthermore, we will also show our trials and strategies by using systems biology methods, to reveal the molecular mechanism on how the surgery on intestine breaks the diabetes robustness.
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