ゲノム情報科学研究教育機構  アブストラクト
Date Apr 18, 2013
Speaker Dr. Hanaa Hibishy, Tanta University, Egypt
Title Cloning and Functional Characterization of PTPCD2 a Novel Cell Cycle Related Protein Tyrosine Phosphatase That Regulates Mitotic Exit
Abstract Proper progression of mitosis requires spatio-temporal regulation of protein phosphorylation by orchestrated activities of kinases and phosphatases. Although many kinases are relatively well characterized in the context of their physiological functions at mitosis and regulation of their enzymatic activities during mitotic progression, phosphatases involved are largely unknown. Here we identified a novel cell cycle related protein tyrosine phosphatase containing domain 2 (Ptpcd 2) that regulates mitotic exit. Overexpression of this phosphatase induced mitotic exit with multinucleation. Its SH2 domains predict a role in signalling transduction particularly dephosphorylation of MAPK pathway. Its chromatin association during interphase, may reflect a role in dephosphorylation of nuclear targets to induce mitotic exit. Moreover, its C-terminal PDZ domain required for tumor suppression could put Ptpcds as an unidentified tumor suppressors. Finally, targeting mitotic exit in malignant cells could open new avenues for anti-cancer therapeutics.
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