アブストラクト
| Date | 2:00pm Jul 24, 2019 |
| Speaker |
Gyorgy Bagdy, MSc, PharmD, PhD, DSc , full professor of pharmacology, and director of the Department of Pharmacodynamics, and the past Vice Rector for Scientific and International Affairs of Semmelweis University, Budapest, Hungary. His main research interest is the pathophysiology, genomics and pharmacology of anxiety, depression and sleep disorders including molecular, in vivo animal, and human studies. He works in EU funded research consortia in the field of neuropsychopharmacology and pharmacogenomics. He has published more than 200 scientific papers in international journals with a cumulative impact factor of about 600, and has over 6000 citations on his works. His Hirsch index is 47. He is the member of several boards and international professional scientific societies including Academia Europaea. |
| Title | Gene-environment and gene-gene interactions: clues to the "missing heritability" enigma in major depression? |
| Abstract | Single genetic variations only account for very limited heritability of common diseases: the "missing heritability" problem. Depression is an extreme example being a polygenic and multifactorial disorder, strongly impacted by environmental effects. Mostly the effect of stressors on the genetic contribution to depression is neglected. The few significant genes in GWASs are related to neurogenesis, neuronal synapse, cell contact and DNA transcription, and less suitable for therapeutic exploration. In contrast, many candidate genes in replicable GxE interactions are connected to stress and the HPA axis and could serve as drug targets. We propose that careful phenotyping and detailed measurement of time, type and severity of environmental factors, and the application of innovative statistical method may lead to novel pharmacological targets and a new understanding of the genetic background of the disorder. |