アブストラクト
| Date | 14:00-15:00 Dec 25, 2023 |
| Speaker | Risa K Kawaguchi Center for iPS Cell Research and Application (CiRA) Kyoto University |
| Title | Beyond Nature and Nurture: Does Stochastic Noise Change the Cellular Epigenetic Landscape? |
| Abstract |
While genetic variation frequently drives phenotypic variability, genetically identical individuals still exhibit distinctively different phenotypic traits. This can be because of rare somatic mutations, environmental fluctuations, or stochastic effects in early development. Although understanding these sources of variation is important to understanding incomplete penetrance and heritability in genetic diseases, it has been difficult to trace their relative influence, particularly due to confounding environmental factors. In this talk, I will introduce our time-course transcriptome analysis on the nine-banded armadillo (Dasypus novemcinctus), which produce litters of genetically identical quadruplets. By demonstrating supervised learning for the prediction of the identity of siblings only from transcriptome profiles, our results indicated the existence of identity signatures under tight control of genetic and environmental factors. Finally, I will discuss our ongoing work, where the transcriptome and epigenetic variability is further assessed on large-scale omics data including hundreds of hPSC lines. |